Summary
Many patients take medications for years without reassessing whether they still need them, creating potential risks and side effects that outweigh the benefits. This article explores practical strategies clinicians use to safely reduce or eliminate long-term medications when appropriate, drawing on expert guidance from experienced practitioners. Learn how to center patient concerns, approach deprescribing diagnostically, and address underlying health issues before tapering medications.
- Contributor
- Staff
- Published
- July 20, 2026
- Contributors


Andrzej Kulesza · Lauren Williams · Craig Mortensen
Center the Reason to Ease Defenses

Andrzej Kulesza, Co-Founder & Medical Director
Deprescribing legacy medications is one of the more consistent challenges in our practice. From years on the front lines of emergency medicine before transitioning to addiction treatment, and now in our inpatient clinic where patients regularly arrive on 6-12 medications with unclear or outdated indications, the approach that has produced the safest outcomes is one specific reframing.
The step: I ask patients "what problem was this medication originally solving, and is that problem still your problem today?" Not "do you still need this?" That question triggers defensive reactions. The reframing shifts the conversation from the medication itself to the underlying reason for the prescription. Often the patient discovers they cannot remember why they started it, or the original stressor (a divorce, a bereavement, a job transition) resolved years ago while the medication persisted.
This works because it removes the implicit accusation ("you have been taking something unnecessary") and replaces it with collaborative curiosity. It also produces the clinical information I actually need: what the medication was originally meant to do, whether the condition still exists, and whether the medication is still doing what was intended or has become a background variable no one is auditing.
The check I add after: I ask them to describe how they would feel differently if the medication were reduced. Patients who answer with specific fears ("my sleep will collapse," "the panic will come back") get slower tapers with clear reintroduction protocols. Patients who answer vaguely ("I don't really know") often tolerate much faster reductions than the original prescriber would have predicted.